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KMID : 0359720210390030202
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Journal of the Korean Neurological Association
2021 Volume.39 No. 3 p.202 ~ p.206
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Cyclophosphamide-Associated Reversible Cerebral Vasoconstriction Syndrome Presenting as Concurrent Cerebral Infarction and Subarachnoid Hemorrhage
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Jeong Dong-Young
Kim Keon-Woo
Park Yun-Jik
Kim Yeon-Jung
Chang Jun-Young
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Abstract
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Reversible cerebral vasoconstriction syndrome (RCVS) has several trigger factors, including physical exertion, pregnancy, and the intake of vasoconstrictive agents. These triggers activate the sympathetic nervous system and induce vasoconstriction, thereby leading to an ischemic or hemorrhagic stroke. In this study, we describe case of RCVS in a 73-year-old woman who complained of sudden bilateral leg weakness after taking cyclophosphamide for anti-neutrophil cytoplasmic antibody associated vasculitis. She was diagnosed with concurrent cerebral hemorrhage and cerebral infarction with multiple intracranial vasoconstrictions on imaging analyses.
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KEYWORD
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Cyclophosphamide, Vasoconstriction, Ischemic stroke, Hemorrhagic stroke
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